Wall Street ends flat as rally slows, earnings eyed

NEW YORK (Reuters) - Stocks ended little changed on Friday as investors took a step back from buying ahead of next week's busy corporate earnings calendar.

Overall earnings are expected to grow by just 1.9 percent in this season, according to Thomson Reuters data. Analysts say that, with the bar low, there's room for companies to beat expectations, and that may have contributed to the rise in stocks so far in 2013.

That rally has slowed in the last few days.

"It's a market that is waiting for more of a catalyst from earnings," said Quincy Krosby, market strategist at Prudential Financial in Newark, New Jersey.

The S&P 500 index has gained 5 percent over the last two weeks to take the benchmark to five-year highs.

Wells Fargo & Co set a weak tone Friday after it reported results. It showed lower fourth-quarter net interest margin - a key measure of how much money banks make from loans - even as profit jumped.

The bank, which was the first major financial institution to report results this earnings season, also made fewer mortgage loans than in the third quarter.

Wells Fargo ended down 0.8 percent at $35.10, off its lows for the day, while bank shares weighed on the broader market. The S&P 500 financial sector index <.gspf> fell 0.3 percent after rallying more than 1 percent on Thursday.

Bank of America Corp , JPMorgan Chase & Co and Citigroup Inc are due to report results next week, as are other major companies including General Electric and Intel .

An agreement reached in Washington at the start of the year over the "fiscal cliff" saw investors in U.S.-based funds add $7.53 billion to stock mutual funds in the week ended Jan 9, the most since 2001, data from Thomson Reuters' Lipper service showed.

"The money poured into the market at the beginning of the year and you're going to need new money to bring this market higher," said Krosby. She said that in the short-term the market has a bias toward moving higher, even though it is overbought.

The Dow Jones industrial average <.dji> gained 17.21 points, or 0.13 percent, to 13,488.43. The Standard & Poor's 500 Index <.spx> dipped 0.07 points to 1,472.05. The Nasdaq Composite Index <.ixic> added 3.88 points, or 0.12 percent, to 3,125.64.

For the week, the S&P and Dow both gained 0.4 percent and the Nasdaq rose 0.8 percent.

Boeing weighed on the Dow after a cracked cockpit window and an oil leak on separate flights in Japan added to problems with some of its Dreamliner 787 jets, compounding safety concerns about the new aircraft.

The U.S. Department of Transportation said the jet would be subject to a review of its critical systems by regulators. Boeing was the biggest loser on the Dow, falling 2.5 percent to $75.16.

Best Buy rallied after its results showed a small turnaround in U.S. stores, though same-store sales were flat during the key holiday season. Its shares jumped 16.4 percent to $14.21, making it the best performer on the S&P 500.

Dendreon Corp surged 21 percent to $6.17 after Sanford C. Bernstein upgraded the drugmaker's stock to "outperform" from "market-perform" and said it could be one of the best performers in 2013.

Volume was below the 2012 average of 6.42 billion shares traded a day, with roughly 5.93 billion shares changing hands on the New York Stock Exchange, the Nasdaq and the NYSE MKT.

Advancers outpaced decliners on the New York Stock Exchange by 1,578 to 1,393, while advancers narrowly outnumbered decliners on the Nasdaq by 1,228 to 1,223.

(Editing by Nick Zieminski)

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Zorbing Accident Kills 1 Man and Injures Another in Russia

MOSCOW — It is called a zorb, an outsize inflatable ball in which people strap themselves, then bounce down a ski slope and, presumably, have a good time doing so. But when a zorb veered off a ski run high in Russia’s Caucasus Mountains earlier this month, there was little anyone could do but watch as the two men inside careened along a jagged ridge and then plunged over a precipice.

The ball tumbled down the mountain at the Dombai ski resort for almost a mile, slamming into rocks as it picked up speed, rescue workers said on Wednesday in a televised statement. One of the men, Denis Burakov, 27, injured his spinal cord and died on the way to a hospital. The other, Vladimir Shcherbakov, 33, suffered a concussion and deep cuts to his arms and face.

The accident on Jan. 3, which a friend of the men filmed on a cellphone and then uploaded to the Internet on Tuesday, has generated concern over unlicensed attractions on Russia’s loosely regulated ski slopes.

The man who harnessed Mr. Burakov and Mr. Shcherbakov into the zorb told the police that they were his first customers, and that he was not licensed to offer rides, having bought the ball two years ago for his own use. On Thursday the police arrested the man, Ravil Chekunov, 25, who said he had charged Mr. Burakov and Mr. Shcherbakov about $10 for the ride.

Russia’s minister of emergency situations called Wednesday for tighter safety precautions at skiing facilities, after a rash of winter sports injuries. Russian television reported this week that 10 people had been seriously injured on a single ski slope in Kolomna, a city 50 miles southeast of Moscow. A woman who descended on a sled broke her spine after she ran into rocks at the bottom.

Russian leaders, notably President Vladimir V. Putin, have tried for years to build interest in downhill skiing in Russia. The country has invested billions of dollars in ski resorts in the Caucasus, and in particular in the Black Sea resort of Sochi, which will host the Winter Olympics in 2014.

Mr. Putin mingled with stunned vacationers at a resort near Sochi during the winter break, and the culture minister, Vladimir R. Medinsky, lavishly praised the local ski conditions on Twitter.

But an investigation into the accident at the Dombai ski resort, less than 100 miles east of Sochi, found 50 unlicensed attractions and guides operating on the mountain, the newspaper Izvestia reported.

A Moscow-based businessman, Montay Imanov, told Izvestia that the zorb that carried the two men was stolen from him at gunpoint in 2009, when he traveled to the region intending to open a zorbing business.

“They didn’t cordon the track off from the gorge,” he said. “It’s just a nightmare. They needed to put six rows of nets there.”

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Jimmy Dushku: The 25-year-old who is North Korea’s one true Twitter friend

Mother Jones takes a look at a globetrotting young investor who’s the only American — and the only human being — Pyongyang follows

Google Chairman Eric Schmidt capped a controversial four-day visit to North Korea on Thursday with a call for the country’s censorship-happy communist government to give its people access to the internet, or face further economic decline due to the country’s global isolation. It was a strong message from one of the web’s most powerful figures, although North Korea watchers seem pretty confident the country’s young leader, Kim Jong Un, will ignore it. There’s one American, however, Pyongyang does appear to listen to. That would be Jimmy Dushku, a young investor who is one of exactly three Twitter users Kim’s government follows on Twitter. What’s the story behind this unlikely online bromance? Here, a guide:

Who is Jimmy Dushku?
He’s a 25-year-old financial whiz kid from Austin, Texas. Dushku, who also goes by the nicknames “Jimmer” and “Jammy,” started a website development business when he was 14, according to Mother Jones, and he parlayed his early earnings into investments that now include everything from construction projects in Europe to real estate in Texas to mines in South America. He’s also a rabid Coldplay fan, and when he isn’t jetting around the world, he says he likes to play Rachmaninoff on his piano and zoom around on his Ducati Monster motorcycle.

SEE MORE: North Korea’s rocket launch: 3 consequences

So how did he become buddies with North Korea?
Dushku tells Asawin Suebsaeng at Mother Jones he’s not really sure. “People always ask me how it happened, and I honestly can’t remember,” he says. “It started sometime back in 2010. I was initially surprised.” North Korea followed him, he followed North Korea “out of courtesy.” He tweeted back, “Hello my friend,” and a relationship was born. Then, the North Korean government, which has piled up some 11,000 followers in two-and-a-half years on Twitter, abruptly whittled down the number of accounts it follows, leaving just three. Dushku made the cut (along with a Vietnam account and another official North Korean handle).

What has Dushku gotten from the relationship?
Death threats, for one thing. Not long after he linked up with North Korea’s account, which goes by @uriminzok (or “our nation”), Dushku says he started getting angry messages from exiles and South Koreans. Since then, he has mostly kept a low profile, just to be safe, although he does occasionally grant interviews to foreign publications. For its part, North Korea gets a rare glimpse at the outside world through Dushku, as his is the only account North Korea follows that is regularly updated — the other two haven’t tweeted in months. He’s also the only human being in the bunch.

Will @JimmyDushku and @uriminzok ever meet in real life?
That’s always the question for acquaintances who meet online, isn’t it? Dushku says his friendly relationship has won him a standing offer to visit North Korea. Casual observers, however, advise him to proceed with caution. “Am I the only one thinking they picked some random guy so they can lure him into North Korea and use him as a political prisoner/bargaining chip?” one commenter at Gizmodo said. Another suggests that Dushku play it cool, without making Pyongyang angry, saying, “Never unfollow anybody with nuclear weapons.”

Sources: Austinist, CNN, Gizmodo, Mother Jones

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Dumb Criminal: Juan Ramirez Tijerina Packed for Jail Break

01/10/2013 at 05:30 PM EST

Give him an "A" for ingenuity.

Four years into a 20-year sentence for illegal weapons possession, Juan Ramirez Tijerina had had enough of life in the pokey. After a conjugal visit in July 2011 with his partner, Maria del Carmen Arjona Rivero, he was packed and ready to go – literally.

Ramirez was apprehended after officers, noticing that Arjona seemed nervous as she headed for the prison exit in Chetumal, Mexico, with a bulging suitcase, unzipped the bag and found the convict inside.

He's back behind bars, and Arjona was detained.

"This is rare," says a prison spokesman. "Most of the inmates here dig tunnels, try to jump fences or take advantage of a riot to escape."

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Flu season strikes early and, in some places, hard

NEW YORK (AP) — From the Rocky Mountains to New England, hospitals are swamped with people with flu symptoms. Some medical centers are turning away visitors or making them wear face masks, and one Pennsylvania hospital set up a tent outside its ER to deal with the feverish patients.

Flu season in the U.S. has struck early and, in many places, hard.

While flu normally doesn't blanket the country until late January or February, it is already widespread in more than 40 states, with about 30 of them reporting some major hotspots. On Thursday, health officials blamed the flu for the deaths of 20 children so far.

Whether this will be considered a bad season by the time it has run its course in the spring remains to be seen.

"Those of us with gray hair have seen worse," said Dr. William Schaffner, a flu expert at Vanderbilt University in Nashville.

The evidence so far points to a moderate season, Schaffner and others say. It looks bad in part because last year was unusually mild and because the main strain of influenza circulating this year tends to make people sicker and really lay them low.

David Smythe of New York City saw it happen to his 50-year-old girlfriend, who has been knocked out for about two weeks. "She's been in bed. She can't even get up," he said.

Also, the flu's early arrival coincided with spikes in a variety of other viruses, including a childhood malady that mimics flu and a new norovirus that causes vomiting and diarrhea, or what is commonly known as "stomach flu." So what people are calling the flu may, in fact, be something else.

"There may be more of an overlap than we normally see," said Dr. Joseph Bresee, who tracks the flu for the Centers for Disease Control and Prevention.

Most people don't undergo lab tests to confirm flu, and the symptoms are so similar that it can be hard to distinguish flu from other viruses, or even a cold. Over the holidays, 250 people were sickened at a Mormon missionary training center in Utah, but the culprit turned out to be a norovirus, not the flu.

Flu is a major contributor, though, to what's going on.

"I'd say 75 percent," said Dr. Dan Surdam, head of the emergency department at Cheyenne Regional Medical Center, Wyoming's largest hospital. The 17-bed emergency room saw its busiest day ever last week, with 166 visitors.

The early onslaught has resulted in a spike in hospitalizations. To deal with the influx and protect other patients from getting sick, hospitals are restricting visits from children, requiring family members to wear masks and banning anyone with flu symptoms from maternity wards.

One hospital in Allentown, Pa., set up a tent this week for a steady stream of patients with flu symptoms. But so far "what we're seeing is a typical flu season," said Terry Burger, director of infection control and prevention for the hospital, Lehigh Valley Hospital-Cedar Crest.

On Wednesday, Boston declared a public health emergency, with the city's hospitals counting about 1,500 emergency room visits since December by people with flu-like symptoms.

All the flu activity has led some to question whether this year's flu shot is working. While health officials are still analyzing the vaccine, early indications are that it's about 60 percent effective, which is in line with what's been seen in other years.

The vaccine is reformulated each year, based on experts' best guess of which strains of the virus will predominate. This year's vaccine is well-matched to what's going around. The government estimates that between a third and half of Americans have gotten the vaccine.

In New York City, 57-year-old Judith Quinones suffered her worst case of flu-like illness in years and was laid up for nearly a month with fever and body aches. "I just couldn't function," she said.

She decided to skip getting a flu shot last fall. But her daughter got the shot. "And she got sick twice," Quinones said.

Europe is also suffering an early flu season, though a milder strain predominates there. Flu reports are up, too, in China, Japan, the West Bank, the Gaza Strip, Algeria and the Republic of Congo. Britain has seen a surge in cases of norovirus.

On average, about 24,000 Americans die each flu season, according to the CDC.

Flu usually peaks in midwinter. Symptoms can include fever, cough, runny nose, head and body aches and fatigue. Some people also suffer vomiting and diarrhea, and some develop pneumonia or other severe complications.

Most people with flu have a mild illness and can help themselves and protect others by staying home and resting. But people with severe symptoms should see a doctor. They may be given antiviral drugs or other medications to ease symptoms.

Flu vaccinations are recommended for everyone 6 months or older. Of the 20 children killed by the flu this season, only two were fully vaccinated.

___

AP Medical Writer Maria Cheng in London contributed to this report.

___

Online:

CDC flu: http://www.cdc.gov/flu/index.htm

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Wall Street climbs as China data puts S&P back at five-year high

NEW YORK (Reuters) - Stocks rose on Thursday and the S&P 500 ended at a fresh five-year high as stronger-than-expected exports from China spurred optimism about global growth prospects.

Buying accelerated late in the day after the S&P 500 broke through technical resistance at 1,466.47, which was the market's closing level last Friday and the highest level since December 2007.

"Historically, January is a positive month for the market and you're seeing that play out," said Michael Sheldon, chief market strategist at RDM Financial in Westport, Connecticut.

Financial and energy stocks were the day's top gainers. The financial sector index <.gspf> rose 1.4 percent and the energy sector <.gspe> was up 1 percent.

Analysts cited economic data out of China as the day's catalyst, which showed the country's export growth rebounded sharply to a seven-month high in December, a strong finish to the year after seven straight quarters of slowdown.

"It is being interpreted positively that they've stopped the downturn (in growth)," said Kurt Brunner, portfolio manager at Swarthmore Group in Philadelphia.

"If they continue to produce good growth, that's going to be supportive of our global manufacturers."

Wall Street's fear gauge, the CBOE Volatility Index <.vix> suggested markets were relatively calm. The VIX was down 2.3 percent at 13.49.

At Thursday's close, the S&P sits about 6 percent below its all-time closing high of 1,565.15, hit in October 2007.

The Dow Jones industrial average <.dji> gained 80.71 points, or 0.60 percent, to 13,471.22. The Standard & Poor's 500 Index <.spx> rose 11.10 points, or 0.76 percent, to 1,472.12. The Nasdaq Composite Index <.ixic> added 15.95 points, or 0.51 percent, to 3,121.76.

Thursday's session had earlier included a dip that traders said was triggered by a trade in the options market that prompted a large amount of S&P futures to hit the market at the same time. That sent the S&P 500 index down rapidly but those losses were reversed through the afternoon.

Financials benefited from events this week that added clarity to mortgage rules and banks' potential exposure to the housing market.

The U.S. government's consumer finance watchdog announced mortgage rules on Thursday that will force banks to use new criteria to determine whether a borrower can repay a home loan.

Earlier this week, several big mortgage lenders reached a deal with regulators to end a review of foreclosures mandated by the government.

"It's a resolution. It's not hanging over their heads," said Brunner.

Bank of America gained 3.1 percent to $11.78, while Morgan Stanley was up 3.7 percent at $20.34, one day after sources said the bank plans to cut jobs.

Shares of upscale jeweler Tiffany dropped 4.5 percent to $60.40 after it said sales were flat during the holidays.

Herbalife Ltd stepped up its defense against activist investor Bill Ackman, stressing it was a legitimate company with a mission to improve nutrition and help public health. The stock ended down 1.8 percent at $39.24 after a volatile day.

After the closing bell, American Express said it would cut about 5,400 jobs, and take about $600 million in after-tax charges in the fourth quarter. The stock added 0.7 percent to $61.20 in after-hours trade.

Volume was above the 2012 average of 6.42 billion shares traded a day, with roughly 6.77 billion shares changing hands on the New York Stock Exchange, the Nasdaq and the NYSE MKT.

Advancers outnumbered decliners on the NYSE by 1,916 to 1,039, while advancers also outpaced decliners on the Nasdaq by 1,439 to 1,036.

(Editing by Nick Zieminski)

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Venezuelan Court: Chávez Swearing-In Can Be Postponed

CARACAS, Venezuela (AP) — Venezuelan opposition leader Henrique Capriles is condemning the Supreme Court's endorsement of a delay in President Hugo Chavez's inauguration.

The Supreme Court sided with Venezuela's government and ruling party earlier Wednesday in the heated dispute with the opposition while the ailing leader struggles with complications a month after cancer surgery in Cuba.

Capriles says that "institutions should not respond to the interests of a government."

Supreme Court President Luisa Estella announced that it's legal for lawmakers to delay Chavez's swearing-in for a new term, which had been scheduled for Thursday.

Pro-Chavez lawmakers voted Tuesday to delay the ceremony, allowing Chavez to take the oath of office at a later date before the Supreme Court.

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Men and Women of (Limited) Letters: Must-Follow Twitter Accounts of 2013

Scientific American editors voted in recent weeks on the 20 most informative Twitter accounts to stay abreast of the latest ideas, issues and developments in science and technology. We weeded through hundreds of lists and feeds to select the most brilliant and engaging, as well as the quirkiest of the bunch.Our picks are often witty, sometimes eccentric and occasionally silly, but each brings valuable insights to his or her area of expertise. For the latest, greatest tweets on science, technology, journalism, astronomy, physics, mathematics and more, check out these top 20 Twitter accounts of 2013, listed here in alphabetical order.

Must-Follow Twitter Accounts of 2013

Next » BBC Science @BBCscience

 Pay attention to BBC Science for breaking science and environmental news from a global perspective. Tweets are most often serious, with the occasional story about whether a toilet seat really is the dirtiest item in the house. The BBC offers variety suitable to both the casual consumer and the diehard nerd.

« Previous Intro

Must-Follow Twitter Accounts of 2013

Next » Deborah Blum @DeborahBlum

Deborah Blum’s tweets about poison, murder and other interesting articles and quips aren’t all that make her Twitter feed unique. It also stands out for her insights into science journalism. Blum often posts jobs, tips and tricks of the trade that will motivate any aspiring science blogger to break out the laptop and start posting.
By day, Sean Carroll is a theoretical physicist. By night he’s a “truth vigilante.” The Caltech researcher writes lofty pieces about eternity and dark matter, and tweets fascinating facts about his field.

 This NASA Twitter account gained notoriety when the car-size rover Curiosity landed on Mars in August 2012. With its witty persona, pop culture references and updates on its forays across the surface of the Red Planet, @MarsCuriosity is a must-follow for 2013—and the rest of its multiyear tour. Also check out the “Curiosity Explorer” badge on Foursquare and watch the rover’s New Year’s Eve message on YouTube
David Dobbs is an accomplished science journalist who is big on audience engagement in the new media milieu. His Twitter feed is punctuated with responses to readers weighing in on a wide variety of topics, especially cognitive science. Dobbs also tweets sporadically about his personal life and his work for Wired. He’s working on his fifth book.
Maryn McKenna, a specialist on food policy, public health and infectious disease, has built and cultivated a dedicated online following. Her tweets and posts are smart, quirky and highly informative. A seasoned science journalist, she uses social media to nerd out on a daily basis, so join in the geeky fun.
Former Scientific American special projects guru Christopher Mims isn’t shy. Opinionated and straightforward, the technology and sustainability journalist, now at QuartzNews, stays ahead of the pack. Mims frequently engages with his audience and uses crowd-sourcing to gather material for many of his stories.
Scientific American editors enjoy checking in on Nature News‘s hard-nosed, clever twitter feed.  One might suspect that our favor for it derives from the fact that Scientific American is also part of Nature Publishing Group, but we actually operate as editorially independent units. Follow Nature News especially for investigative reporting on science scandals and international science policy, as well as the latest important biomedical and physics news.

 Founder and CEO of O’Reilly Media Tim O’Reilly reports technology trends and comments on advocacy issues. His Twitter feed is dominated by references to Silicon Valley and e-book deals. Follow his tweets for insightful coverage of the technical world.
John Allen Paulos is a PhD with character. He’s wearing a bow tie in his profile picture, and his favored emoticon is a winking smiley face. Paulos’s tweets can be a tad cryptic for the layperson, but the mathematician has such a great sense of humor that you’re sure to laugh out loud at some point—even if you don’t quite understand the joke.
Accomplished blogger Phil Plait has just migrated his popular “Bad Astronomy” blog to Slate. The author, skeptic, father and punster primarily covers the ins and outs of the solar system. The best part about Plait’s Twitter feed is his daily #BAFact, wherein he throws strange-but-true scraps of science to his curious followers.

 Veteran science journalist Paul Raeburn has turned his eye in recent years to good-natured meta-media, covering science reporting itself for the Knight Science Journalism Tracker while also covering reseach on fatherhood. Raeburn takes reporters to task for sloppy thinking, points out inaccuracies and addresses ethical dilemmas. Follow his account just to read the back-and-forth between him and his targets.
Andy Revkin is a leader in the environmental reporting field, covering everything from fracking to global warming. Check out Revkin’s DotEarth blog in The New York Times too for his breaking news coverage—it’s all the environmental news that’s fit to cover.

 Science Friday, part of National Public Radio’s Talk of the Nation radio program, packs its Twitter feed with tantalizing links that just beg to be clicked on. @SciFri looks at daily news through a scientific lens, including live tweets to provide context during the weekly broadcast. The result is an entertaining bundle of scientific discoveries, intrigues and debunkings.
Scientific American‘s contributors are a brilliant group of reporters, bloggers and commentators, if you’ll pardon this moment of pride. Creativity, skepticism and authoritative context are a big part of what makes our coverage so engaging and worthwhile. Check out this Twitter list and follow your favorites.
Nate Silver, the most celebrated political statistician of the 2012 election, started out as a forecaster of baseball player performance. When he turned his attention to U.S. presidential elections, using statistical models to accurately predict what was thought to be unpredictable, he became a sensation. Although this past year’s electoral frenzy is behind us, Silver is still at work making predictions we’d be foolish to ignore.
Steven Strogatz holds the esteem of math wunderkinds as well as those who are iffy on formulas. He’s hardly a typical numbers-cruncher. The Cornell University professor has a knack for taking on complex topics and making them interesting, even to full-on mathphobes. In his recent book, The Joy of X, discussions range from the number of people one should date before settling down to how HBO’s The Sopranos can help us understand calculus. His Twitter account is similarly entertaining.
Not following Neil DeGrasse Tyson on Twitter? Beware: science nerds who don’t wake up each morning to the rational witticisms of NGT in their feed risk losing all geek cred. If you fit this description, please remedy that situation—now.
Blogger Ed Yong diligantly weaves a love of data into his prose, while still managing to craft posts that are accessible to readers with little to no science background. By covering new findings skeptically and tweeting prolifically, he has built a readership that relies on him for science news. Join the club.
A self-described “champion of underappreciated life-forms,” Carl Zimmer tends to tackle stories about parasites, viruses and quantum earthworms. Follow his feed, probably the most followed of any science writer, for solid reporting and captivating writing.

« Previous Ed Yong @EdYong209

Must-Follow Twitter Accounts of 2013

Restart the list » Introduction

Follow Scientific American on Twitter @SciAm and @SciamBlogs.Visit ScientificAmerican.com for the latest in science, health and technology news.
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David Bowie's New Single Is No Splashy Comeback

By Chuck Arnold

01/09/2013 at 05:00 PM EST

"Where Are We Now?" ponders a plaintive David Bowie on his comeback single after seemingly retiring from music. Indeed, this august, atmospheric ballad previews his first album in 10 years, The Next Day, due out March 12.

Out of nowhere the song was dropped in the middle of the night on Jan. 8 – which just happens to be Bowie's birthday (he turned 66). The low-key release certainly suits the understated tone of the tune, which is hardly the splashy comeback one might have expected from the glam god who was once Ziggy Stardust.

Instead, Bowie plays the reflective elder statesman dispensing some existential lyrics: "The moment you know, you know you know."

While the track – produced by Tony Visconti, who also worked on the star's Berlin Trilogy from 1977 to 1979 – ultimately doesn't give many answers, it at least tells us where Bowie has been lately. And it's a welcome return from one of our great rock heroes.

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Retooling Pap test to spot more kinds of cancer

WASHINGTON (AP) — For years, doctors have lamented that there's no Pap test for deadly ovarian cancer. Wednesday, scientists reported encouraging signs that one day, there might be.

Researchers are trying to retool the Pap, a test for cervical cancer that millions of women get, so that it could spot early signs of other gynecologic cancers, too.

How? It turns out that cells can flake off of tumors in the ovaries or the lining of the uterus, and float down to rest in the cervix, where Pap tests are performed. These cells are too rare to recognize under the microscope. But researchers from Johns Hopkins University used some sophisticated DNA testing on the Pap samples to uncover the evidence — gene mutations that show cancer is present.

In a pilot study, they analyzed Pap smears from 46 women who already were diagnosed with either ovarian or endometrial cancer. The new technique found all the endometrial cancers and 41 percent of the ovarian tumors, the team reported Wednesday in the journal Science Translational Medicine.

This is very early-stage research, and women shouldn't expect any change in their routine Paps. It will take years of additional testing to prove if the so-called PapGene technique really could work as a screening tool, used to spot cancer in women who thought they were healthy.

"Now the hard work begins," said Hopkins oncologist Dr. Luis Diaz, whose team is collecting hundreds of additional Pap samples for more study and is exploring ways to enhance the detection of ovarian cancer.

But if it ultimately pans out, "the neat part about this is, the patient won't feel anything different," and the Pap wouldn't be performed differently, Diaz added. The extra work would come in a lab.

The gene-based technique marks a new approach toward cancer screening, and specialists are watching closely.

"This is very encouraging, and it shows great potential," said American Cancer Society genetics expert Michael Melner.

"We are a long way from being able to see any impact on our patients," cautioned Dr. Shannon Westin of the University of Texas MD Anderson Cancer Center. She reviewed the research in an accompanying editorial, and said the ovarian cancer detection would need improvement if the test is to work.

But she noted that ovarian cancer has poor survival rates because it's rarely caught early. "If this screening test could identify ovarian cancer at an early stage, there would be a profound impact on patient outcomes and mortality," Westin said.

More than 22,000 U.S. women are diagnosed with ovarian cancer each year, and more than 15,000 die. Symptoms such as pain and bloating seldom are obvious until the cancer is more advanced, and numerous attempts at screening tests have failed.

Endometrial cancer affects about 47,000 women a year, and kills about 8,000. There is no screening test for it either, but most women are diagnosed early because of postmenopausal bleeding.

The Hopkins research piggybacks on one of the most successful cancer screening tools, the Pap, and a newer technology used along with it. With a standard Pap, a little brush scrapes off cells from the cervix, which are stored in a vial to examine for signs of cervical cancer. Today, many women's Paps undergo an additional DNA-based test to see if they harbor the HPV virus, which can spur cervical cancer.

So the Hopkins team, funded largely by cancer advocacy groups, decided to look for DNA evidence of other gynecologic tumors. It developed a method to rapidly screen the Pap samples for those mutations using standard genetics equipment that Diaz said wouldn't add much to the cost of a Pap-plus-HPV test. He said the technique could detect both early-stage and more advanced tumors. Importantly, tests of Paps from 14 healthy women turned up no false alarms.

The endometrial cancers may have been easier to find because cells from those tumors don't have as far to travel as ovarian cancer cells, Diaz said. Researchers will study whether inserting the Pap brush deeper, testing during different times of the menstrual cycle, or other factors might improve detection of ovarian cancer.

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